Most air ambulance services offer operations 24 hours a day, 7 days a week across the United States or internationally. A patient or hospital advocate can contact an air ambulance operations center where a flight coordinator helps determine the medical needs and estimate on the transfer. Then the transfer of the patient from ground ambulance to air ambulance takes place.

Operations air ambulance centers determines the type of air transport needed. From Lear jets to twin engine propeller aircraft to helicopters, air ambulances are completely equipped with the latest in medical transport equipment.  Lear Jets are the most prevalent air ambulance aircraft due to its range, flexibility, flight comfort and reliability. They are typically best equipped for longer distances than other forms of air ambulance aircraft.